Most studies analyze the rheumatoid factor IgM, and there is no unanimity in whether patients with FRIga have a worse prognosis. When polyarthritis is analyzed with few months of evolution, the rheumatoid factor constitutes the main factor that predicts the persistence of the disease (and the opposite situation Keto Viante: seronegativity predicts high remission rates).
This is one of the most repeated variables in established AR and would be largely related to the delay in the introduction of antirheumatic therapy. A significant degree of impairment of functional capacity at the onset of the disease is a factor of poor prognosis and usually predicts future disability, although it can be reversed in part with antirheumatic therapy.
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